Phospho-mouse FADD(S191) Antibody Blocking peptide
€363.00
In stock
SKU
AC-BP3103a
Background:
FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Protein FADD, Fadd, Mort1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3103a was selected from the region of human Mouse Phospho-FADD-S191. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: Fadd {ECO:0000303|PubMed:8649383, ECO:0000312|MGI:MGI:109324}
Gene ID: 14082
Primary Accession: Q61160
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
FADD is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Other Names:
FAS-associated death domain protein, FAS-associating death domain-containing protein, Mediator of receptor induced toxicity, Protein FADD, Fadd, Mort1
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP3103a was selected from the region of human Mouse Phospho-FADD-S191. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: Fadd {ECO:0000303|PubMed:8649383, ECO:0000312|MGI:MGI:109324}
Gene ID: 14082
Primary Accession: Q61160
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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