Phospho-mouse p21Cip1(S125) Blocking Peptide
€363.00
In stock
SKU
AC-BP3875a
Background:
The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Different cyclinsexhibit distinct expression and degradation patterns whichcontribute to the temporal coordination of each mitotic event. Thiscyclin forms a complex with and functions as a regulatory subunitof CDK4 or CDK6, whose activtiy is required for cell cycle G1/Stransition. This protein has been shown to interact with and beinvolved in the phosphorylation of tumor suppressor protein Rb. TheCDK4 activity associated with this cyclin was reported to benecessary for cell cycle progression through G2 phase into mitosisafter UV radiation. Several transcript variants encoding differentisoforms have been found for this gene.
Other Names:
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1
Target/Specificity:
The synthetic peptide sequence is selected from aa 119-132 of MOUSE Cdkn1a
Gene Name: Cdkn1a
Gene ID: 12575
Primary Accession: P39689
Other Accession: NP_001129489.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
The protein encoded by this gene belongs to the highlyconserved cyclin family, whose members are characterized by adramatic periodicity in protein abundance through the cell cycle.Cyclins function as regulators of CDK kinases. Different cyclinsexhibit distinct expression and degradation patterns whichcontribute to the temporal coordination of each mitotic event. Thiscyclin forms a complex with and functions as a regulatory subunitof CDK4 or CDK6, whose activtiy is required for cell cycle G1/Stransition. This protein has been shown to interact with and beinvolved in the phosphorylation of tumor suppressor protein Rb. TheCDK4 activity associated with this cyclin was reported to benecessary for cell cycle progression through G2 phase into mitosisafter UV radiation. Several transcript variants encoding differentisoforms have been found for this gene.
Other Names:
Cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, Melanoma differentiation-associated protein, p21, Cdkn1a, Cip1, Waf1
Target/Specificity:
The synthetic peptide sequence is selected from aa 119-132 of MOUSE Cdkn1a
Gene Name: Cdkn1a
Gene ID: 12575
Primary Accession: P39689
Other Accession: NP_001129489.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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