Phospho-mouse TSC2(S1343) polyclonal, anti-mouse
€0.00
In stock
SKU
AC-AP3823a
Catalog Number: AC-AP3823a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB41255
Applications: DB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB41255
Applications: DB
Datasheet
Request Information
Background:
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Other Names:
Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2
Target/Specificity:
This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1343 of mouse TSC2.
Antigen Type: Synthetic Peptide
Gene Name: Tsc2 {ECO:0000303|PubMed:8777431, ECO:0000312|MGI:MGI:102548}
Primary Accession: Q61037
Other Accession: P49816
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity). Specifically stimulates the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. Suggesting a possible mechanism for its role in regulating cellular growth (By similarity).
Other Names:
Tuberin, Tuberous sclerosis 2 protein homolog, Tsc2
Target/Specificity:
This mouse TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1343 of mouse TSC2.
Antigen Type: Synthetic Peptide
Gene Name: Tsc2 {ECO:0000303|PubMed:8777431, ECO:0000312|MGI:MGI:102548}
Primary Accession: Q61037
Other Accession: P49816
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review