Phospho-NF kappa B(S536) polyclonal, anti-human
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In stock
SKU
AC-AP3749a
Catalog Number: AC-AP3749a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22552
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB22552
Applications: DB
Datasheet
Request Information
Background:
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex.The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form ofNFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA,MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB bytrapping it in the cytoplasm. Phosphorylation of serine residues onthe I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM603258) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NFKB complex. Activated NFKBcomplex translocates into the nucleus and binds DNA atkappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).
Other Names:
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Target/Specificity:
This NF kappa B Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NF kappa B.
Antigen Type: Synthetic Peptide
Gene Name: RELA
Gene ID: 5970
Primary Accession: Q04206
NCBI Accession: NP_001138610.1;NP_001230913.1;NP_068810.3
Other Accession: Q04207; NP_068810.3; NP_001138610.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is bound to REL(MIM 164910), RELA, or RELB (MIM 604758) to form the NFKB complex.The p50 (NFKB1)/p65 (RELA) heterodimer is the most abundant form ofNFKB. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA,MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB bytrapping it in the cytoplasm. Phosphorylation of serine residues onthe I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM603258) marks them for destruction via the ubiquitination pathway,thereby allowing activation of the NFKB complex. Activated NFKBcomplex translocates into the nucleus and binds DNA atkappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or Gpurine; and Y is a C or T pyrimidine).
Other Names:
Transcription factor p65, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, NFKB3
Target/Specificity:
This NF kappa B Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S536 of human NF kappa B.
Antigen Type: Synthetic Peptide
Gene Name: RELA
Gene ID: 5970
Primary Accession: Q04206
NCBI Accession: NP_001138610.1;NP_001230913.1;NP_068810.3
Other Accession: Q04207; NP_068810.3; NP_001138610.1
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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