Phospho-NF-kB p65(S536) Polyclonal Antibody

Background:
NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene.

Research Area: Cancer, Cell Biology, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Microbiology, Neuroscience, Signal Transduction

Synonyms:
NFKB3, p65, NF-kB p65, RELA, CMCU

Immunogen: A phospho specific peptide corresponding to residues surrounding S536 of human NF-kB p65

Swissprot: Q04206
Gene ID: 5970

Calculated MW: 58 kDa/59 kDa/60 kDa
Observed MW: 71 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000 IHC 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.