Phospho-NFkB p100(S866) Polyclonal Antibody

Background:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Signal Transduction

Synonyms:
CVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p49/p100, p52

Immunogen: A phospho specific peptide corresponding to residues surrounding S866 of human NFkB p100

Swissprot: Q00653
Gene ID: 4791

Calculated MW: 47 kDa/96 kDa
Observed MW: 120 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.