Phospho-P38 (Thr180/Tyr182) Polyclonal Antibody

Background:
MAPK14(mitogen-activated protein kinase 14) is also named as SAPK2A, p38MAPK, CSBP1, RK, p38, EXIP, Mxi2, CSBP2, PRKM14, PRKM15, CSPB1, p38ALPHA and belongs to the MAP kinase subfamily. MAPK14-signaling is a central pathway for the integration of instructive signals in dendritic cells for T(H)17 differentiation and inflammation(PMID:22231518). It plays an important role in the regulation of hematopoietic stem cellself-renewal in vitro and inhibition of MAPK14 activation with a small molecule inhibitor may represent a novel approach to promote ex vivo expansion of hematopoietic stem cell(PMID:21198398). This protein has 4 isoforms produced by alternative splicing.

Research Area: Cancer, Immunology, Signal Transduction

Synonyms:
CSAID Binding Protein 1, CSAID binding protein, CSAID-binding protein, Csaids binding protein, CSBP 1, CSBP 2, CSBP, CSBP1, CSBP2, CSPB1, Cytokine suppressive anti-inflammatory drug-binding protein, EXIP, MAP kinase 14, MAP kinase MXI2, MAP kinase p38 alpha, MAPK 14, MAPK14, MAX interacting protein 2, MAX-interacting protein 2, Mitogen Activated Protein Kinase 14, Mitogen activated protein kinase p38 alpha, Mitogen-activated protein kinase 14, Mitogen-activated protein kinase p38 alpha, MK14, Mxi 2, MXI2, p38 ALPHA, p38, p38 MAP kinase, p38 MAPK, p38 mitogen activated protein kinase, p38ALPHA, p38alpha Exip, PRKM14, PRKM15, RK, SAPK2A

Immunogen: Synthesized peptide derived from human p38 around the phosphorylation site of Thr180/Tyr182

Swissprot: Q16539

Calculated MW: 41 kDa
Observed MW: 38 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4

Concentration: 1 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:5000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-535,sc-7149,sc-728

Citation(s):
https://www.sciencedirect.com/science/article/pii/S1567576918312372
https://pubmed.ncbi.nlm.nih.gov/32423183/