Phospho-p53 polyclonal, anti-human, mouse, rat antibody
€465.00
In stock
SKU
AC-ABV10376-100
Catalog Number: AC-ABV10376-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, IP
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC, IP
Datasheet
Request Information
Background:
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15, the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.
Other Names:
TP53 , p53 , LFS1 , TRP53 , P53 , tumor protein p53 , Li-Fraumeni syndrome
Primary Accession: P04637
Other Accession: EAW90140
Gene Name: TP53
Gene ID: 7157
Concentration (mg/ml): 0.5 mg/ml
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15, the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.
Other Names:
TP53 , p53 , LFS1 , TRP53 , P53 , tumor protein p53 , Li-Fraumeni syndrome
Primary Accession: P04637
Other Accession: EAW90140
Gene Name: TP53
Gene ID: 7157
Concentration (mg/ml): 0.5 mg/ml
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