Phospho-PDPK1(S396) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3458a
Catalog Number: AC-AP3458a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13093
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB13093
Applications: DB
Datasheet
Request Information
Background:
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Other Names:
3-phosphoinositide-dependent protein kinase 1, hPDK1, PDPK1, PDK1
Target/Specificity:
This PDPK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S396 of human PDPK1.
Antigen Type: Synthetic Peptide
Gene Name: PDPK1
Gene ID: 5170
Primary Accession: O15530
NCBI Accession: NP_001248745.1;NP_002604.1;NP_112558.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases. PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop. PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis. Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.
Other Names:
3-phosphoinositide-dependent protein kinase 1, hPDK1, PDPK1, PDK1
Target/Specificity:
This PDPK1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S396 of human PDPK1.
Antigen Type: Synthetic Peptide
Gene Name: PDPK1
Gene ID: 5170
Primary Accession: O15530
NCBI Accession: NP_001248745.1;NP_002604.1;NP_112558.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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