Phospho-Raf polyclonal, anti-human, mouse, rat antibody
€375.00
In stock
SKU
AC-ABV10373-100
Catalog Number: AC-ABV10373-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IHC
Datasheet
Request Information
Background:
c-Raf is a mitogen-activated protein kinase. Binding of Raf to 14-3-3 is required for c-Raf kinase activity, and also blocks the ability of phosphatase to inhibit c-Raf. 14-3-3 binds c-Raf at two phospho-serine residues: Ser259 and Ser621. Mutation of Ser259 to alanine constitutively activates Raf kinase activity, but mutation of Ser621 to alanine results in an inactive kinase.
Other Names:
RAF1 , cRaf , Raf-1 , c-Raf , RAF , CRAF , C-RAF, RAF proto-oncogene serine/threonine-protein kinase;Proto-oncogene c-RAF, cRaf, Raf-1
Primary Accession: P04049
Gene Name: RAF1
Gene ID: 5894
Concentration (mg/ml): 0.5 mg/ml
c-Raf is a mitogen-activated protein kinase. Binding of Raf to 14-3-3 is required for c-Raf kinase activity, and also blocks the ability of phosphatase to inhibit c-Raf. 14-3-3 binds c-Raf at two phospho-serine residues: Ser259 and Ser621. Mutation of Ser259 to alanine constitutively activates Raf kinase activity, but mutation of Ser621 to alanine results in an inactive kinase.
Other Names:
RAF1 , cRaf , Raf-1 , c-Raf , RAF , CRAF , C-RAF, RAF proto-oncogene serine/threonine-protein kinase;Proto-oncogene c-RAF, cRaf, Raf-1
Primary Accession: P04049
Gene Name: RAF1
Gene ID: 5894
Concentration (mg/ml): 0.5 mg/ml
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