Phospho-RAF1(S43) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3332a
Catalog Number: AC-AP3332a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11127
Applications: DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11127
Applications: DB
Datasheet
Request Information
Background:
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Other Names:
RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF
Target/Specificity:
This RAF1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S43 of human RAF1.
Antigen Type: Synthetic Peptide
Gene Name: RAF1 (HGNC:9829)
Gene ID: 5894
Primary Accession: P04049
NCBI Accession: NP_002871.1
Other Accession: P11345; Q99N57; A7E3S4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Other Names:
RAF proto-oncogene serine/threonine-protein kinase, Proto-oncogene c-RAF, cRaf, Raf-1, RAF1, RAF
Target/Specificity:
This RAF1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S43 of human RAF1.
Antigen Type: Synthetic Peptide
Gene Name: RAF1 (HGNC:9829)
Gene ID: 5894
Primary Accession: P04049
NCBI Accession: NP_002871.1
Other Accession: P11345; Q99N57; A7E3S4
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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