Phospho-Rb (Ser780) rabbit polyclonal, anti-human, mouse, rat

Backgroud: Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression. Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation. Specificity of different CDK/cyclin complexes has been observed in vitro and cyclin D1 is required for Ser780 phosphorylation in vivo.

Synonyms: RB1, Retinoblastoma-associated protein, p105-Rb, pRb, Rb, pp110

Gene Name: RB1

Gene ID: 5925

SwissProt ID: P06400

Purification: Affinity Chromatography

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.