Phospho-RB1(S780) Polyclonal Antibody

Background:
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Research Area: Cancer, Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
OSRC, PPP1R130, RB, p105-Rb, pRb, pp110, RB1, Rb

Immunogen: A phospho specific peptide corresponding to residues surrounding S780 of human RB1

Swissprot: P06400
Gene ID: 5925

Calculated MW: 106 kDa
Observed MW: 100 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.