Phospho-SMAD2(S118) polyclonal, anti-human
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In stock
SKU
AC-AP3654a
Catalog Number: AC-AP3654a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18941
Applications: DB, IF
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB18941
Applications: DB, IF
Datasheet
Request Information
Background:
The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
Other Names:
Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2
Target/Specificity:
This SMAD2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S118 of human SMAD2.
Antigen Type: Synthetic Peptide
Gene Name: SMAD2
Gene ID: 4087
Primary Accession: Q15796
NCBI Accession: NP_001003652.1;NP_005892.1
Other Accession: O54835; Q9JIW5; O15198; Q9R1V3; P97454; Q99717; Q9W7E7; Q56I99; P84025; P84024; Q8BUN5; P84022; P84023; O70436; Q62432; Q9I9P9; Q1W668; P97588; P70340; Q15797; Q9I8V2; Q1JQA2; P42003
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The protein belongs to the SMAD, a family of proteins similar to the proteins of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin.
Other Names:
Mothers against decapentaplegic homolog 2, MAD homolog 2, Mothers against DPP homolog 2, JV18-1, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, hSMAD2, SMAD2, MADH2, MADR2
Target/Specificity:
This SMAD2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S118 of human SMAD2.
Antigen Type: Synthetic Peptide
Gene Name: SMAD2
Gene ID: 4087
Primary Accession: Q15796
NCBI Accession: NP_001003652.1;NP_005892.1
Other Accession: O54835; Q9JIW5; O15198; Q9R1V3; P97454; Q99717; Q9W7E7; Q56I99; P84025; P84024; Q8BUN5; P84022; P84023; O70436; Q62432; Q9I9P9; Q1W668; P97588; P70340; Q15797; Q9I8V2; Q1JQA2; P42003
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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