Phospho-SNCA(S129) Polyclonal Antibody

Background:
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Research Area: Cancer, Neuroscience

Synonyms:
PD1, NACP, PARK1, PARK4, SNCA

Immunogen: A phospho specific peptide corresponding to residues surrounding S129 of human SNCA

Swissprot: P37840
Gene ID: 6622

Calculated MW: 11 kDa/13 kDa/14 kDa
Observed MW: 20 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.