Phospho-Stat5 polyclonal, anti-human, mouse, rat antibody
€355.00
In stock
SKU
AC-ABV10346-100
Catalog Number: AC-ABV10346-100
Size: 100 µg
Host: Rabbit IgG
Applications: WB, IF
Datasheet
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Size: 100 µg
Host: Rabbit IgG
Applications: WB, IF
Datasheet
Request Information
Background:
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Altho µgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Other Names:
Anti-Stat-5, STAT-5
Primary Accession: P42230
Other Accession: NP_035618
Gene Name: Stat5a
Gene ID: 20850
Concentration (mg/ml): 0.5 mg/ml
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Altho µgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.
Other Names:
Anti-Stat-5, STAT-5
Primary Accession: P42230
Other Accession: NP_035618
Gene Name: Stat5a
Gene ID: 20850
Concentration (mg/ml): 0.5 mg/ml
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