Phospho-STAT5a(S726) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3266a
Catalog Number: AC-AP3266a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5945
Applications: WB, IHC-P, DB
Datasheet
Request Information
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5945
Applications: WB, IHC-P, DB
Datasheet
Request Information
Background:
STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.
Other Names:
Signal transducer and activator of transcription 5A, STAT5A, STAT5
Target/Specificity:
This STAT5a Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S726 of human STAT5a.
Antigen Type: Synthetic Peptide
Gene Name: STAT5A
Gene ID: 6776
Primary Accession: P42229
NCBI Accession: NP_003143.2
Other Accession: Q9TUZ0; P51692; Q9TUM3; Q9TUZ1; Q95115; P42231
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
STAT5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this protein is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this protein in cells.
Other Names:
Signal transducer and activator of transcription 5A, STAT5A, STAT5
Target/Specificity:
This STAT5a Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S726 of human STAT5a.
Antigen Type: Synthetic Peptide
Gene Name: STAT5A
Gene ID: 6776
Primary Accession: P42229
NCBI Accession: NP_003143.2
Other Accession: Q9TUZ0; P51692; Q9TUM3; Q9TUZ1; Q95115; P42231
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
|---|
Write Your Own Review