Phospho-Stat6 polyclonal, anti-human, mouse antibody

Background:
Membrane receptor signaling by various ligands induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the ISGF3 transcription factor complex. Altho µgh early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 is activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Other Names:
STAT6B , STAT6C , D12S1644 , IL-4-STAT , interleukin 4 induced STAT

Primary Accession: P42226

Other Accession: NP_003144

Gene Name: STAT6

Gene ID: 6778

Concentration (mg/ml): 0.5 mg/ml