Phospho-SYN1(S9) Polyclonal Antibody

Background:
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.

Research Area: Cancer, Neuroscience

Synonyms:
SYN1, SYN1a, SYN1b, SYNI

Immunogen: A phospho specific peptide corresponding to residues surrounding S9 of human SYN1

Swissprot: P17600
Gene ID: 6853

Calculated MW: 70 kDa/74 kDa
Observed MW: 74 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000 IF 1:100-1:200"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.