Phospho-TBK(S172) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3627a
Catalog Number: AC-AP3627a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB16573
Applications: WB, DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB16573
Applications: WB, DB
Datasheet
Request Information
Background:
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Other Names:
Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, TBK1, NAK
Target/Specificity:
This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.
Antigen Type: Synthetic Peptide
Gene Name: TBK1 {ECO:0000303|PubMed:10581243, ECO:0000312|HGNC:HGNC:11584}
Gene ID: 29110
Primary Accession: Q9UHD2
NCBI Accession: NP_037386.1
Other Accession: Q6DFJ6; Q9WUN2; NP_037386; Q1JPV3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
Other Names:
Serine/threonine-protein kinase TBK1, NF-kappa-B-activating kinase, T2K, TANK-binding kinase 1, TBK1, NAK
Target/Specificity:
This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.
Antigen Type: Synthetic Peptide
Gene Name: TBK1 {ECO:0000303|PubMed:10581243, ECO:0000312|HGNC:HGNC:11584}
Gene ID: 29110
Primary Accession: Q9UHD2
NCBI Accession: NP_037386.1
Other Accession: Q6DFJ6; Q9WUN2; NP_037386; Q1JPV3
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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