Phospho-TrkA(Y490) Polyclonal Antibody

Background:
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

Research Area: Cancer, Neuroscience

Synonyms:
NTRK1, MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA

Immunogen: A phospho specific peptide corresponding to residues surrounding Y490 of human TrkA

Swissprot: P04629
Gene ID: 4914

Calculated MW: 77 kDa/83 kDa/86 kDa/87 kDa
Observed MW: 150 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:2000"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.