Phospho-TSC2(S939) polyclonal, anti-human
€0.00
In stock
SKU
AC-AP3415a
Catalog Number: AC-AP3415a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11386
Applications: IF, DB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB11386
Applications: IF, DB
Datasheet
Request Information
Background:
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Other Names:
Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Target/Specificity:
This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S939 of human TSC2.
Antigen Type: Synthetic Peptide
Gene Name: TSC2 {ECO:0000303|PubMed:7558029, ECO:0000312|HGNC:HGNC:12363}
Gene ID: 7249
Primary Accession: P49815
NCBI Accession: NP_000539.2;NP_001070651.1;NP_001107854.1
Other Accession: Q61037
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
Other Names:
Tuberin, Tuberous sclerosis 2 protein, TSC2, TSC4
Target/Specificity:
This TSC2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S939 of human TSC2.
Antigen Type: Synthetic Peptide
Gene Name: TSC2 {ECO:0000303|PubMed:7558029, ECO:0000312|HGNC:HGNC:12363}
Gene ID: 7249
Primary Accession: P49815
NCBI Accession: NP_000539.2;NP_001070651.1;NP_001107854.1
Other Accession: Q61037
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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