Phospho-ZAP70(Y493) Polyclonal Antibody

Background:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

Research Area: Cancer, Immunology, Signal Transduction, Tags and Cell Markers

Synonyms:
ZAP70, ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70

Immunogen: A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70

Swissprot: P43403
Gene ID: 7535

Calculated MW: 35 kDa/55 kDa/69 kDa
Observed MW: 70 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:2000-1:5000 IHC 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.