PHOX2A antibody (clone 4F6), anti-human, rat
€435.00
In stock
SKU
AC-AT3303a
Catalog Number: AC-AT3303a
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IFhttps://www.abcepta.com/products/pdf_download/AT3303a-PHOX2A-Antibody-monoclonal-M01">Request Information AC-AT3303a">Request Information
Size: 100 µg
Isotype: mouse IgG2a Kappa
Applications: WB, IFhttps://www.abcepta.com/products/pdf_download/AT3303a-PHOX2A-Antibody-monoclonal-M01">Request Information AC-AT3303a">Request Information
Background:
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
Other Names:
Paired mesoderm homeobox protein 2A, ARIX1 homeodomain protein, Aristaless homeobox protein homolog, Paired-like homeobox 2A, PHOX2A, ARIX, PMX2A
Antigen Type:
Recombinant Protein
Gene Name: PHOX2A
Gene ID: 401
NCBI Accession: NP_005160.2
Primary Accession: O14813
Other Accession: NM_005169
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles.
Other Names:
Paired mesoderm homeobox protein 2A, ARIX1 homeodomain protein, Aristaless homeobox protein homolog, Paired-like homeobox 2A, PHOX2A, ARIX, PMX2A
Antigen Type:
Recombinant Protein
Gene Name: PHOX2A
Gene ID: 401
NCBI Accession: NP_005160.2
Primary Accession: O14813
Other Accession: NM_005169
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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