PHOX2B Polyclonal Antibody

Background:
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

Research Area: Cancer, Epigenetics and Nuclear Signaling, Neuroscience

Synonyms:
PHOX2B, NBLST2, NBPhox, PMX2B

Immunogen: Recombinant fusion protein of human PHOX2B (NP_003915.2).

Swissprot: Q99453
Gene ID: 8929

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.