PI3 polyclonal, anti-human, rat
€388.00
In stock
SKU
BS7777
Background:
Elafin, also known as elastase-specific inhibitor (ESI) or skin-derived anti-leukoproteinase (SKALP), is a low molecular weight elastase inhibitor derived from psoriatic skin. Elafin is found in the epidermis of several inflammatory skin diseases, but not in normal human epidermis. It is found in the urine of psoriatic patients, and immunohistochemical studies show that elafin is found in the suprabasal differentiated keratinocytes of psoriatic epidermis. In inflamed skin, elafin exists both as a free form and as an immobilized form covalently attached to the cornified envelopes by transglutaminase cross-linking. Although there is no allelic association between pustular psoriasis (or psoriasis in general) and polymorphism of the PI3 gene, a decrease of elafin is found in lesional skin of patients with pustular psoriasis compared with plaque-type psoriasis.
Alternative Name:
Cementoin, ELAF_HUMAN, Elafin, Elastase Specific Inhibitor, Elastase-specific inhibitor, ES 1, ESI, Peptidase inhibitor 3, Peptidase inhibitor 3, skin derived, PI 3, PI-3, PI3, Pre elafin, Protease inhibitor 3 skin derived, Protease inhibitor 3, skin derived (SKALP), Protease inhibitor WAP3, SKALP, Skin derived Anti leukoproteinase, Skin-derived antileukoproteinase, Trappin 2, WAP four disulfide core domain 14, WAP four disulfide core domain protein 14, WAP four-disulfide core domain protein 14, WAP3, WFDC14,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PI3 polyclonal antibody detects endogenous levels of PI3 protein.
Immunogen:
Recombinant full length Human PI3.
MW: ~ 12 kDa
Swis Prot.: P19957
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Elafin, also known as elastase-specific inhibitor (ESI) or skin-derived anti-leukoproteinase (SKALP), is a low molecular weight elastase inhibitor derived from psoriatic skin. Elafin is found in the epidermis of several inflammatory skin diseases, but not in normal human epidermis. It is found in the urine of psoriatic patients, and immunohistochemical studies show that elafin is found in the suprabasal differentiated keratinocytes of psoriatic epidermis. In inflamed skin, elafin exists both as a free form and as an immobilized form covalently attached to the cornified envelopes by transglutaminase cross-linking. Although there is no allelic association between pustular psoriasis (or psoriasis in general) and polymorphism of the PI3 gene, a decrease of elafin is found in lesional skin of patients with pustular psoriasis compared with plaque-type psoriasis.
Alternative Name:
Cementoin, ELAF_HUMAN, Elafin, Elastase Specific Inhibitor, Elastase-specific inhibitor, ES 1, ESI, Peptidase inhibitor 3, Peptidase inhibitor 3, skin derived, PI 3, PI-3, PI3, Pre elafin, Protease inhibitor 3 skin derived, Protease inhibitor 3, skin derived (SKALP), Protease inhibitor WAP3, SKALP, Skin derived Anti leukoproteinase, Skin-derived antileukoproteinase, Trappin 2, WAP four disulfide core domain 14, WAP four disulfide core domain protein 14, WAP four-disulfide core domain protein 14, WAP3, WFDC14,
Application Dilution: WB: 1:500~1:2000, IHC: 1:50~1:200
Specificity: PI3 polyclonal antibody detects endogenous levels of PI3 protein.
Immunogen:
Recombinant full length Human PI3.
MW: ~ 12 kDa
Swis Prot.: P19957
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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