PIAS1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
E3 SUMO-protein ligase PIAS1 is an enzyme that in humans is encoded by the PIAS1 gene. It is mapped to 15q23. This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1(signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. PIAS1 inhibited STAT1-mediated gene activation in response to interferon when expressed in mammalian cells. It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. On the other hand, PIAS1 also can function as a SUMO ligase, or possibly as a tightly bound regulator of it, toward p53.

Description:
Rabbit IgG polyclonal antibody for E3 SUMO-protein ligase PIAS1 (PIAS1) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat.

Synonyms:
DDXBP1 antibody, DEAD/H box binding protein 1 antibody, DEAD/H box-binding protein 1 antibody, E3 SUMO-protein ligase PIAS1 antibody, GBP antibody, Gu binding protein antibody, Gu-binding protein antibody, Pias1 antibody, PIAS1_HUMAN antibody, Protein inhibitor of activated STAT protein 1 antibody, RNA helicase II binding protein antibody, RNA helicase II-binding protein antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human PIAS1(636-651aa DTASIFGIIPDIISLD), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.