PIAS2 Polyclonal Antibody

Background:
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Research Area: Cell Biology, Epigenetics and Nuclear Signaling

Synonyms:
Androgen receptor interacting protein 3, Androgen receptor-interacting protein 3, ARIP3, DAB2 interacting protein, DAB2-interacting protein, DIP, E3 SUMO protein ligase PIAS2, E3 SUMO-protein ligase PIAS2, MIZ, Miz1, Msx interacting zinc finger protein, Msx-interacting zinc finger protein, PIAS NY protein, PIAS-NY protein, PIAS2, PIAS2, PIASX, PIASX-ALPHA, PIASX-BETA, Protein inhibitor of activated STAT x, Protein inhibitor of activated STAT, 2, Protein inhibitor of activated STAT2, SIZ2, Zinc finger, MIZ-type containing 4, ZMIZ4

Immunogen: Synthetic peptide of human PIAS2

Swissprot: O75928
Gene Accession: NP_004662

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.6 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18245/sc-30879/sc-30878