PIAS3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71897
Background:
The IL-6 type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization, and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.
Alternative Name:
E3 SUMO-protein ligase PIAS1, Protein inhibitor of activated STAT protein 1, Gu binding protein, GBP, RNA helicase II binding protein, DEAD/H box-binding protein 1, DDXBP1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100
Specificity: PIAS3 polyclonal antibody detects endogenous levels of PIAS3 protein.
Immunogen:
Recombinant protein of human PIAS3
MW: 68kDa
Swis Prot.: Q9Y6X2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The IL-6 type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization, and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.
Alternative Name:
E3 SUMO-protein ligase PIAS1, Protein inhibitor of activated STAT protein 1, Gu binding protein, GBP, RNA helicase II binding protein, DEAD/H box-binding protein 1, DDXBP1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:100
Specificity: PIAS3 polyclonal antibody detects endogenous levels of PIAS3 protein.
Immunogen:
Recombinant protein of human PIAS3
MW: 68kDa
Swis Prot.: Q9Y6X2
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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