PIAS3 polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP1244a
Catalog Number: AC-AP1244a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0673
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB0673
Applications: WB, IHC-P
Datasheet
Request Information
Background:
PIAS3 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, catalyzing the covalent attachment of a SUMO protein to specific target substrates. PIAS3 plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
Other Names:
E3 SUMO-protein ligase PIAS3, 632-, Protein inhibitor of activated STAT protein 3, PIAS3
Target/Specificity:
This PIAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-619 amino acids of human PIAS3.
Antigen Region:
588-619
Antigen Type: Synthetic Peptide
Gene Name: PIAS3
Gene ID: 10401
Primary Accession: Q9Y6X2
NCBI Accession: NP_006090.2
Other Accession: O70260; O54714
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
PIAS3 is a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor, catalyzing the covalent attachment of a SUMO protein to specific target substrates. PIAS3 plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing, may vary depending upon the biological context.
Other Names:
E3 SUMO-protein ligase PIAS3, 632-, Protein inhibitor of activated STAT protein 3, PIAS3
Target/Specificity:
This PIAS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 588-619 amino acids of human PIAS3.
Antigen Region:
588-619
Antigen Type: Synthetic Peptide
Gene Name: PIAS3
Gene ID: 10401
Primary Accession: Q9Y6X2
NCBI Accession: NP_006090.2
Other Accession: O70260; O54714
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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