PICK1 polyclonal, anti-human, mouse, rat

Background:
Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.

Alternative Name:
PICK1, PRKCABP, dJ1039K5, MGC15204, OTTHUMP00000028509, PICK 1, Pick1, PICK1, PRKCA binding protein, PRKCA-binding protein, PRKCABP, Protein interacting with C kinase 1, Protein interacting with PRKCA, Protein interacting with PRKCA 1, Protein kinase C alpha binding protein, Protein kinase C-alpha-binding protein, Protein that interacts with C kinase 1,

Application Dilution:
WB:1:2,000-1:5,000
IP:1:10-1:50
FC:1:50-1:100

Specificity: PICK1 polyclonal antibody detects endogenous levels of PICK1 protein.

Immunogen:
Recombinant protein within N-terminal human PICK1.

MW: 47 kDa

Swiss-Prot: Q9NRD5(Human)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.