PID/MTA2 polyclonal (C-term), anti-human, mouse
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SKU
AC-AP6663b
Catalog Number: AC-AP6663b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20031
Applications: WB, FC, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB20031
Applications: WB, FC, IHC-P
Datasheet
Request Information
Background:
MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small family of different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Other Names:
Metastasis-associated protein MTA2, Metastasis-associated 1-like 1, MTA1-L1 protein, p53 target protein in deacetylase complex, MTA2, MTA1L1, PID
Target/Specificity:
This PID/MTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-544 amino acids from the C-terminal region of human PID/MTA2.
Antigen Region:
516-544
Antigen Type: Synthetic Peptide
Gene Name: MTA2
Gene ID: 9219
Primary Accession: O94776
NCBI Accession: NP_004730.2
Other Accession: Q9R190
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
MTA2 is a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small family of different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Other Names:
Metastasis-associated protein MTA2, Metastasis-associated 1-like 1, MTA1-L1 protein, p53 target protein in deacetylase complex, MTA2, MTA1L1, PID
Target/Specificity:
This PID/MTA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 516-544 amino acids from the C-terminal region of human PID/MTA2.
Antigen Region:
516-544
Antigen Type: Synthetic Peptide
Gene Name: MTA2
Gene ID: 9219
Primary Accession: O94776
NCBI Accession: NP_004730.2
Other Accession: Q9R190
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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