PIDD (AL233) polyclonal, anti-human, mouse

Quantity: 100 µl

Description:
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Synonyms:
p53-induced Protein with a Death Domain, Leucine-rich Repeat and Death Domain-containing Protein, Lrdd

Isotype: Rabbit Polyclonal

Immunogen:
Recombinant human PIDD (Death Domain: aa 776-910).

Form: Purified, in PBS containing 10% glycerol and 0.02% sodium azide.

Specificity:
Recognizes human and the native form of mouse PIDD. Detects bands of ~90kDa (full length protein) and ~50kDa (cleaved protein) by Western blot.

Reactivity: human, mouse

Applications: Immunohistochemistry, Immunoprecipitation, Western Blot

Working DIlution: Optimal conditions must be determined individually for each application.

Storage: 2-8C immediate use, or -20C (aliquoted)