PIDD (clone Lise-1), anti-mouse

Decription:
PIDD promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. It associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. It associates with caspase-2 and RAIDD, and induces activation of caspase-2 which is an important regulator in the apoptotic pathways.

Synonyms: p53-induced Protein with a Death Domain, Leucine-rich Repeat and Death Domain-containing Protein, Lrdd

Clone: Lise-1

Isotype: MouseﾠIgG2b kappa

Immunogen: Mouse PIDD (Death Domain).

Reactivity: mouse

Specificity: Recognizes mouse PIDD.

Form: Purified, in PBS containing 10% glycerol andﾠ0.02% sodium azide.

Applications: Western Blot: (1:1'000)

Working Dilution: Optimal conditions must be determined individually for each application.

Concentration: 1mg/ml

Storage: 2-8C immediate use, or -20C (aliquote)