PIDD Polyclonal Antibody

Background:
The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Research Area: Cell Biology

Synonyms:
PIDD1, LRDD, PIDD

Immunogen: Recombinant fusion protein of human PIDD (NP_665893.2).

Swissprot: Q9HB75
Gene ID: 55367

Calculated MW: 33 kDa/37 kDa/58 kDa/66 kDa/82 kDa/97 kDa/99 kDa
Observed MW: 100-110 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Concentration: 1 mg/mL
Dilution: "WB 1:500-1:1000 IHC 1:50-1:200 IF 1:50-1:100"

Storage:
Store at -20°C. Avoid freeze / thaw cycles.