PIGF polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61239
Background:
Phosphatidylinositol-glycans(PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs exhibit various functions but all are crucial for the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor. Some PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Other PIGs belong to the glycosyl transferase complex and function in the transfer of N-acetylglucosamine (GlcNAc) to phosphatidyli nositol (PI). A variety of other PIGs play distinct rolesin GPI synthesis. PIG-F functions as an auxiliary subunit of ethanolamine phosphate (EtNP) transferases. It associates with PIG-O and is required for its expression and stability. Together these two PIGs function as an EtNP transferase and catalyze the transfer of EtNP to the third mannose (Man-3) of GPI. Amutation in the gene encoding PIG-Fmayresult in a block of EtNP addition to Man-3 and lead to an absence of GPI-anchored proteins.
Alternative Name:
Phosphatidylinositol-glycan biosynthesis class F protein, PIG-F, GPI11 homolog, PIGF
Application Dilution: WB: 1:500~1:1000
Specificity: PIGF polyclonal antibody detects endogenous levels of PIGF protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PIGF.
MW: ~ 24 kDa
Swis Prot.: Q07326
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Phosphatidylinositol-glycans(PIGs) are multi-pass transmembrane proteins that localize to the endoplasmic reticulum. PIGs exhibit various functions but all are crucial for the biosynthesis of the glycosyl phosphatidylinositol (GPI) anchor. Some PIG proteins are components of the GPI transamidase complex and play a role in the recognition of either the GPI attachment signal or the lipid portion of GPI. Other PIGs belong to the glycosyl transferase complex and function in the transfer of N-acetylglucosamine (GlcNAc) to phosphatidyli nositol (PI). A variety of other PIGs play distinct rolesin GPI synthesis. PIG-F functions as an auxiliary subunit of ethanolamine phosphate (EtNP) transferases. It associates with PIG-O and is required for its expression and stability. Together these two PIGs function as an EtNP transferase and catalyze the transfer of EtNP to the third mannose (Man-3) of GPI. Amutation in the gene encoding PIG-Fmayresult in a block of EtNP addition to Man-3 and lead to an absence of GPI-anchored proteins.
Alternative Name:
Phosphatidylinositol-glycan biosynthesis class F protein, PIG-F, GPI11 homolog, PIGF
Application Dilution: WB: 1:500~1:1000
Specificity: PIGF polyclonal antibody detects endogenous levels of PIGF protein.
Immunogen:
A synthetic peptide corresponding to residues in Human PIGF.
MW: ~ 24 kDa
Swis Prot.: Q07326
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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