PIK3C2A polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71277
Background:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Alternative Name:
CPK, PI3-K-C2A, PI3-K-C2(ALPHA),
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IP: 1:50 - 1:200
Specificity: PIK3C2A polyclonal antibody detects endogenous levels of PIK3C2A protein.
Immunogen:
Recombinant protein of human PIK3C2A.
MW: ~ 191 kDa
Swis Prot.: O00443
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.
Alternative Name:
CPK, PI3-K-C2A, PI3-K-C2(ALPHA),
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IP: 1:50 - 1:200
Specificity: PIK3C2A polyclonal antibody detects endogenous levels of PIK3C2A protein.
Immunogen:
Recombinant protein of human PIK3C2A.
MW: ~ 191 kDa
Swis Prot.: O00443
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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