PIK3C2A polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling.

Synonyms: CPK, PI3-K-C2(ALPHA), PI3-K-C2A, PI3K-C2-alpha, PI3K-C2alpha

Cellular Location: Cell membrane Cytoplasm Cytoplasmic vesicle Golgi apparatus Nucleus clathrin-coated vesicle

Immunogen:
Recombinant protein of human PIK3C2A

Gene Symbol: PIK3C2A

Gene ID: 5286

Swiss prot: O00443

Calculated MW: 191kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-100, IP 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.