PIK3CA polyclonal, anti-human, rat

Quantity: 100 µg

Background:
Phosphatidylinositol-4,5-bisphosphate 3-kinase, also called PIK3CA, is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. PIK3CA gene is mapped to 3q26.32. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P andPtdIns(4,5)P2. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. It has been found to be oncogenic and has been implicated in cervical cancers. PIK3CA mutations in breast cancer may be a predictive marker to guide the selection of patients who would benefit from mTOR inhibitor therapy. In addition to that, the presence of PIK3CA mutation may predict response to aspirin therapy for colorectal cancer, indicating power and promise of "Molecular Pathological Epidemiology (MPE)" approach as well as a complex interaction within the tumor microenvironment in this phenomenon.

Description:
Rabbit IgG polyclonal antibody for Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) detection. Tested with WB in Human, Rat.

Synonyms:
5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha antibody, 5-bisphosphate 3-kinase catalytic subunit alpha isoform antibody, caPI3K antibody, CLOVE antibody, CWS5 antibody, MCAP antibody, MCM antibody, MCMTC antibody, MGC142161 antibody, MGC142163 antibody, p110 alpha antibody, p110alpha antibody, Phosphatidylinositol 3 kinase catalytic alpha polypeptide antibody, Phosphatidylinositol 3 kinase catalytic 110 KD alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha antibody, Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha antibody, Phosphatidylinositol 45 bisphosphate 3 kinase catalytic subunit alpha isoform antibody, Phosphatidylinositol-4 antibody, Phosphoinositide 3 kinase catalytic alpha polypeptide antibody, PI3 kinase p110 subunit alpha antibody, PI3-kinase subunit alpha antibody, PI3K antibody, PI3K-alpha antibody, PI3KC A antibody, PIK3C A antibody, Pik3ca antibody, PK3CA antibody, PK3CA_HUMAN antibody, PtdIns 3 kinase p110 antibody, PtdIns-3-kinase subunit alpha antibody, PtdIns-3-kinase subunit p110-alpha antibody, Serine/threonine protein kinase PIK3CA antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human PIK3CA recombinant protein (Position: H936-N1068). Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.E.coli-derived human PIK3CA recombinant protein (Position: H936-N1068). Human PIK3CA shares 98% amino acid (aa) sequence identity with mouse PIK3CA.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.