PIK3R3 Polyclonal Antibody

Background:
Phosphatidylinositol 3-kinase is a lipid kinase that phosphorylates the inositol ring of phosphatidylinositol and related compounds at the 3’ position. PI 3-kinase p55 (PIK3R3) is comprised of a catalytic subunit and a regulatory subunit. The human p55 protein is composed of a rare amino terminal region followed by a proline-rich motif and two Src homology 2 (SH2) domains. PI 3-kinase p55 mRNAs are expressed in most human fetal and adult tissues; predominant expression is observed in the adult testis. Splice variant(s) of PI 3-kinase p55 have been identified; one of which has a deletion of 36 amino acids at the amino terminus and another which has an insertion of 59 amino acids at position 256 between the SH2 domains. Research suggests that PI 3-kinase p55 interacts with the IGFIR (Insulin-like growth factor-I receptor) and IR (Insulin receptor) and may be involved in PI 3-kinase activation by these receptors.

Research Area: Signal Transduction

Synonyms:
DKFZp686P05226, FLJ41892, OTTHUMP00000009783, OTTHUMP00000009786, p55, p55 gamma, P55G, p55PIK, Phosphatidylinositol 3 kinase regulatory subunit gamma, Phosphatidylinositol 3 kinase regulatory subunit polypeptide 3, Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55, gamma), Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma, Phosphatidylinositol 3-kinase regulatory subunit gamma, Phosphoinositide 3 kinase regulatory subunit 3 (gamma), Phosphoinositide 3 kinase regulatory subunit 3, Phosphoinositide 3 kinase regulatory subunit polypeptide 3, Phosphoinositide 3 kinase, regulatory subunit 3 (p55, gamma), Phosphoinositide 3 kinase, regulatory subunit, polypeptide 3 (p55, gamma), PI3 kinase p85 subunit gamma, PI3-kinase regulatory subunit gamma, PI3-kinase subunit p55-gamma, PI3K regulatory subunit gamma, Pik3r3, PtdIns 3 kinase p85 gamma, PtdIns-3-kinase regulatory subunit gamma, PtdIns-3-kinase regulatory subunit p55-gamma

Immunogen: Synthetic peptide of human PIK3R3

Swissprot: Q92569
Gene Accession: NP_001107644

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: IHC 1:50-1:100

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-48644