PIK3R6 C-terminal region polyclonal, anti-human, mouse, rat, pig, horse, guinea pig

Background:
Regulatory subunit of the PI3K gamma complex. Acts as an adapter to drive activation of PIK3CG by beta-gamma G protein dimers. The PIK3CG:PIK3R6 heterodimer is much less sensitive to beta-gamma G protein dimers than PIK3CG:PIK3R5 and its membrane recruitment and beta-gamma G protein dimer-dependent activation requires HRAS bound to PIK3CG. Recruits of the PI3K gamma complex to a PDE3B:RAPGEF3 signaling complex involved in angiogenesis; signaling seems to involve RRAS.

Other Names:
Phosphoinositide 3-kinase regulatory subunit 6, Phosphoinositide 3-kinase gamma adapter protein of 87 kDa, p84 PI3K adapter protein, p84 PIKAP, p87 PI3K adapter protein, p87PIKAP, PIK3R6, C17orf38

Immunogen:
The immunogen for Anti-PIK3R6 antibody is: synthetic peptide directed towards the C-terminal region of Human PIK3R6

Gene Name:
PIK3R6
Gene Name:
146850
NCBI Accession:
NP_001010855
Primary Accession: Q5UE93
Other Accession: NM_001010855;NP_001010855
Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.