PILRA antibody (clone 3C2), anti-human
€435.00
In stock
SKU
AC-AT3311a
Catalog Number: AC-AT3311a
Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
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Size: 100 µg
Isotype: mouse IgG1 kappa
Applications: WB, E
Request Information AC-AT3311a">Request Information
Background:
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Other Names:
Paired immunoglobulin-like type 2 receptor alpha, Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, PILRA
Antigen Type:
Recombinant Protein
Gene Name: PILRA
Gene ID: 29992
NCBI Accession: NP_038467.2;NP_840056.1;NP_840057.1
Primary Accession: Q9UKJ1
Other Accession: BC017812
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described.
Other Names:
Paired immunoglobulin-like type 2 receptor alpha, Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, PILRA
Antigen Type:
Recombinant Protein
Gene Name: PILRA
Gene ID: 29992
NCBI Accession: NP_038467.2;NP_840056.1;NP_840057.1
Primary Accession: Q9UKJ1
Other Accession: BC017812
Format: Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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