Pin1 polyclonal, anti-human, mouse, rat

Background:
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.

Synonyms: DOD, UBL5, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Cellular Location: Cytoplasm Nucleus

Immunogen:
A synthetic peptide of human Pin1

Gene Symbol: Pin1

Gene ID: 5300

Swiss prot: Q13526

Calculated MW: 18kDa

Recommended dilution:
WB 1:5000-8000, IHC 1:100-300,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.