PINX1 polyclonal, anti-human

Quantity: 100 µg

Background:
PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed TERT protein so that it cannot associate with the telomerase template RNA, which prevents telomerase from being assembled. However, in humans, PINX1 impedes already assembled telomerase.

Description:
Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) detection. Tested with WB in Human.

Synonyms:
67-11-3 protein antibodyFLJ20565 antibody, Hepatocellular carcinoma-related putative tumor suppressor antibody, Liver-related putative tumor suppressor antibody, LPTL antibody, LPTS antibody, MGC8850 antibody, OTTHUMP00000224984 antibody, OTTHUMP00000224985 antibody, OTTHUMP00000224986 antibody, OTTHUMP00000225053 antibody, OTTHUMP00000225054 antibody, PIN2 interacting protein 1 antibody, Pin2-interacting protein X1 antibody, PIN2/TERF1-interacting telomerase inhibitor 1 antibody, PINX1 antibody, PINX1_HUMAN antibody, Protein 67-11-3 antibody, TRF1-interacting protein 1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.