PION Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP12480b
Background:
Accumulation of neurotoxic amyloid-beta is a majorhallmark of Alzheimer disease (AD; MIM 104300). Formation ofamyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM104311), a protease with numerous substrates. PION, or GSAP,selectively increases amyloid-beta production through a mechanisminvolving its interaction with both gamma-secretase and itssubstrate, the amyloid-beta precursor protein (APP; MIM 104760)C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed20811458]).
Other Names:
Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Gene Name: GSAP
Gene ID: 54103
Primary Accession: A4D1B5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Accumulation of neurotoxic amyloid-beta is a majorhallmark of Alzheimer disease (AD; MIM 104300). Formation ofamyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM104311), a protease with numerous substrates. PION, or GSAP,selectively increases amyloid-beta production through a mechanisminvolving its interaction with both gamma-secretase and itssubstrate, the amyloid-beta precursor protein (APP; MIM 104760)C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed20811458]).
Other Names:
Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Gene Name: GSAP
Gene ID: 54103
Primary Accession: A4D1B5
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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