PION polyclonal, anti-human, mouse, rat

Protein Family: Enzymes

Pathway and Disease: Cancers, Neurodegenerative Disorders, Signaling Molecules and Interaction

Description:
Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The beta−amyloid protein precursor (APP) is cleaved by one of two beta−secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma−secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the Alzheimer’s disease patients’ brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer’s disease.

Alternate Names: Protein pigeon homolog, gamma-secretase activating protein, GSAP, PION

Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; IHC: 1:100-1:500

Accession No.: NP_059135

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human PION.

Format: Each vial contains 0.1 ml IgG at 1 mg/ml in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.