PION polyclonal (C-term), anti-human
€0.00
In stock
SKU
AC-AP12480b
Catalog Number: AC-AP12480b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB27384
Applications: IHC-P, WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB27384
Applications: IHC-P, WB
Datasheet
Request Information
Background:
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).
Other Names:
Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Target/Specificity:
This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.
Antigen Region:
537-565
Antigen Type: Synthetic Peptide
Gene Name: GSAP
Gene ID: 54103
Primary Accession: A4D1B5
NCBI Accession: NP_059135.2
Other Accession: NP_059135.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).
Other Names:
Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Target/Specificity:
This PION antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 537-565 amino acids from the C-terminal region of human PION.
Antigen Region:
537-565
Antigen Type: Synthetic Peptide
Gene Name: GSAP
Gene ID: 54103
Primary Accession: A4D1B5
NCBI Accession: NP_059135.2
Other Accession: NP_059135.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
| Is Featured? | No |
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