PIPMT Antibody (N-term) Blocking Peptide
€363.00
In stock
SKU
AC-BP1908a
Background:
Nuclear receptor coactivators participate in the transcriptional activation of specific genes by nuclear receptors. PIPMT contains a 9-amino acid methyltransferase motif I (VVDAFCGVG) and an invariant segment (GXXGXXI) found in K-homology motifs of many RNA-binding proteins. Immunofluorescence studies shows that PIPMT and PRIP proteins are colocalized in the nucleus. PIPMT binds 5-adenosyl-L-methionine, the methyl donor for the methyltransfer reaction, and it also binds RNA, suggesting that it is an RNA methyltransferase. Overexpression of PIPMT enhances the transcriptional activity of PPARG and RXR, and this enhancement is further stimulated by overexpression of PRIP, suggesting that PIPMT is a component of nuclear receptor signal transduction that acts through PRIP.
Other Names:
Trimethylguanosine synthase, 211-, CLL-associated antigen KW-2, Cap-specific guanine-N2 methyltransferase, Hepatocellular carcinoma-associated antigen 137, Nuclear receptor coactivator 6-interacting protein, PRIP-interacting protein with methyltransferase motif, PIMT, PIPMT, TGS1, HCA137, NCOA6IP, PIMT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1908a was selected from the N-term region of human PIPMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TGS1
Gene ID: 96764
Primary Accession: Q96RS0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Nuclear receptor coactivators participate in the transcriptional activation of specific genes by nuclear receptors. PIPMT contains a 9-amino acid methyltransferase motif I (VVDAFCGVG) and an invariant segment (GXXGXXI) found in K-homology motifs of many RNA-binding proteins. Immunofluorescence studies shows that PIPMT and PRIP proteins are colocalized in the nucleus. PIPMT binds 5-adenosyl-L-methionine, the methyl donor for the methyltransfer reaction, and it also binds RNA, suggesting that it is an RNA methyltransferase. Overexpression of PIPMT enhances the transcriptional activity of PPARG and RXR, and this enhancement is further stimulated by overexpression of PRIP, suggesting that PIPMT is a component of nuclear receptor signal transduction that acts through PRIP.
Other Names:
Trimethylguanosine synthase, 211-, CLL-associated antigen KW-2, Cap-specific guanine-N2 methyltransferase, Hepatocellular carcinoma-associated antigen 137, Nuclear receptor coactivator 6-interacting protein, PRIP-interacting protein with methyltransferase motif, PIMT, PIPMT, TGS1, HCA137, NCOA6IP, PIMT
Target/Specificity:
The synthetic peptide sequence used to generate the antibody AP1908a was selected from the N-term region of human PIPMT. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Gene Name: TGS1
Gene ID: 96764
Primary Accession: Q96RS0
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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