PIPOX polyclonal, anti-human, mouse, rat
€305.00
In stock
SKU
BS61669
Background:
PIPOX (pipecolic acid oxidase), also known as LPIPOX or PSO, is a 390 amino acid protein that localizes to the peroxisome and belongs to the MSOX/MTOX family. Existing as a monomer, PIPOX uses FAD as a cofactor to catalyze the metabolism and subsequent degradation of sarcosine, L-pipecolic acid and L-proline. The gene encoding PIPOX maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Alternative Name:
Peroxisomal sarcosine oxidase, PSO, L-pipecolate oxidase, L-pipecolic acid oxidase, PIPOX, LPIPOX, PSO
Application Dilution: WB: 1:500~1:1000
Specificity: PIPOX polyclonal antibody detects endogenous levels of PIPOX protein.
Immunogen:
Synthetic peptide, corresponding Human PIPOX.
MW: ~ 44 kDa
Swis Prot.: Q9P0Z9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PIPOX (pipecolic acid oxidase), also known as LPIPOX or PSO, is a 390 amino acid protein that localizes to the peroxisome and belongs to the MSOX/MTOX family. Existing as a monomer, PIPOX uses FAD as a cofactor to catalyze the metabolism and subsequent degradation of sarcosine, L-pipecolic acid and L-proline. The gene encoding PIPOX maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Alternative Name:
Peroxisomal sarcosine oxidase, PSO, L-pipecolate oxidase, L-pipecolic acid oxidase, PIPOX, LPIPOX, PSO
Application Dilution: WB: 1:500~1:1000
Specificity: PIPOX polyclonal antibody detects endogenous levels of PIPOX protein.
Immunogen:
Synthetic peptide, corresponding Human PIPOX.
MW: ~ 44 kDa
Swis Prot.: Q9P0Z9
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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