PITRM1 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS71185
Background:
PITRM1 (pitrilysin metallopeptidase 1), also known as MP1, PreP, hMP1, KIAA1104, MGC138192 or MGC141929, is a 1,037 amino acid protein belonging to the peptidase M16 family and the PreP subfamily. Encoded by a gene that maps to human chromosome 10p15.2, PITRM1 is widely expressed, with higher levels in muscle and heart compared to brain, pancreas, liver, lung and placenta. PITRM1 is an ATP-independent protease that degrades mitochondrial transit peptides and other unstructured peptides after cleavage. PITRM1 also degrades Amyloid A4 proteins in mitochondrion, suggesting a link with Alzheimer disease. PITRM1 exists as two alternatively spliced isoforms and is specific for peptides in the range of 10 to 65 residues.
Alternative Name:
hPreP, Pitrilysin metalloproteinase 1, Metalloprotease 1, MP1, KIAA1104, MP1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PITRM1 polyclonal antibody detects endogenous levels of PITRM1 protein.
Immunogen:
Recombinant protein of human PITRM1.
MW: ~ 117 kDa
Swis Prot.: Q5JRX3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
PITRM1 (pitrilysin metallopeptidase 1), also known as MP1, PreP, hMP1, KIAA1104, MGC138192 or MGC141929, is a 1,037 amino acid protein belonging to the peptidase M16 family and the PreP subfamily. Encoded by a gene that maps to human chromosome 10p15.2, PITRM1 is widely expressed, with higher levels in muscle and heart compared to brain, pancreas, liver, lung and placenta. PITRM1 is an ATP-independent protease that degrades mitochondrial transit peptides and other unstructured peptides after cleavage. PITRM1 also degrades Amyloid A4 proteins in mitochondrion, suggesting a link with Alzheimer disease. PITRM1 exists as two alternatively spliced isoforms and is specific for peptides in the range of 10 to 65 residues.
Alternative Name:
hPreP, Pitrilysin metalloproteinase 1, Metalloprotease 1, MP1, KIAA1104, MP1
Application Dilution: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200
Specificity: PITRM1 polyclonal antibody detects endogenous levels of PITRM1 protein.
Immunogen:
Recombinant protein of human PITRM1.
MW: ~ 117 kDa
Swis Prot.: Q5JRX3
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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